第 38 卷第 3 期 Vol. 38 No. 3 2008 年 6 月 Jun 2008

所属栏目：香精香料 L-乳酸薄荷酯的合成

童志杰，郑正春 （湖南医药工业研究所 湖南 长沙 410014）

摘　要：以薄荷醇和L-乳酸为原料，用环已烷带水、经酯化、精制得到L-乳酸薄荷酯，并研究了反应时间、醇酸摩尔比、催化剂量对反应的影响，确定的优惠工艺条件为：n（薄荷醇） ∶ n（L-乳酸）=1.2 ∶ 1.0，催化剂为原料总重量2%，环己烷加热回流带水，反应6 h，减压蒸馏至120℃／400 Pa。残余物重结晶，得白色针状结晶产品，收率80%以上，纯度达到99%。

关键词：薄荷醇；乳酸薄荷酯；合成

中图分类号：TQ655　　文献标识码：A　　文章编号：1009-9212（2008）03- 0045-02

Synthesis of Menthol Loctate

TONG Zhi-jie，ZHENG Zheng-chun （Hunan Institute of Pharmaceutical Industry ，Changsha 410014，China）

Abstract：L-Lactic acid peppermint ester was synthesized from menthol and L-lactic acid through esterification in the presence of the cyclohexane including water. And meanwhile factors such as the reaction time，the alcoholacid mole and the catalyst dosage influencing the reaction were investigated, the optimal conditions were obtained as follow: 1.2 ∶ 1.0 of menthol and lactic acid，catalysts 2%（m／m），cyclohexane heat and reflow including water for 6 h，the reduced pressure distillation to 120℃／400 Pa. The residue was recrystallized to the white acicular crystalproduct. The yield and purity was above 80% and 99%，respectively.

Key words：menthol；menthol lactate；synthesis

作者简介：童志杰（1963-），男，湖南长沙人，助理研究员。研究方向：有机合成及应用。

收稿日期：2008-04-14