| 第 31 卷第 5 期 |  | Vol. 31 No. 5 | | 2001 年 10 月 | Oct 2001 |
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所属栏目：其它
TiO_2/SO_4~(2-)型固体酸催化合成丙酮缩二甲醇 |
| 杨淑敏; 王海民; 吕剑; 刘鸿(西安近代化学研究所医药开发部; 陕西西安) |
| 摘 要：原甲酸三甲酯和丙酮在TiO2 /SO4 2 - 型固体酸的催化作用下合成了丙酮缩二甲醇 ,并对诸影响因素进行了考察。在反应温度 0～ 5℃ ,反应时间 1h ,原料配比原甲酸三甲酯∶丙酮∶催化剂 (m /m) =10 6∶5 8∶4的优惠工艺条件下 ,此反应可定量完成 ,精馏分离后收率94 .2 % ,纯度 98.1%。催化剂可重复使用多次。用红外、核磁验证了产物结构 |
| 关键词：丙酮缩二甲醇; TiO2/SO42-固体酸; 合成 |
| 中图分类号：TQ224.4 文献标识码：A 文章编号：1009-9212(2001)05-0026-02 |
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| Catalytic Synthesis of Acetone Dimehtyl Ketal with TiO_2/SO_4~(2-) Solid Acid |
| YANG Shu min; WANG Hai min; LU Jian; LIU Hong （Xi'an Modern Chemistry Research Institute the department of medical development; Shanxi Xi'an 710065） |
| Abstract：Acetone dimethyl acetal was synthesized from trimethyl orthoformate and acetone, the reaction was characterized by the catalysis of TiO 2/SO 4 2- solid acid and quantitative conversion. The influence factors were investigated, the results showed that the optimum conditions were as follows: reaction temperature 0～5℃, reaction time 1h, m(trimethyl orthoformate)∶m(acetone)∶m(solid acid)=106∶58∶4. The solid acid can be used repeatedly. The yield was 94.2% after rectification and the purity was 98.1%.... |
| Key words：acetone dimethyl acetal; TiO 2/SO 4 2- solid acid; synthesis |
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收稿日期：2001-04-17
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