第 39 卷第 6 期 | ![](image2/wentou.gif) | Vol. 39 No. 6 | 2009 年 12 月 | Dec 2009 |
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所属栏目:有机合成原料
微波促进下一步法合成咪唑型离子液体研究 |
孙孟展
(浙江医药高等专科学校 药学系,浙江 宁波 315100) |
摘 要:在微波辐射下,甲基咪唑与1-氯丁烷、四氟硼酸钠3组分一步合成得到离子液体[Bmim]BF4,结构经1H NMR,IR表征。用单因素实验法得到了适宜反应条件:微波功率225 W,反应时间15 min,n(1-氯丁烷) ∶ n(四氟硼酸钠) ∶ n(甲基咪唑)=1.1 ∶ 1.5 ∶ 1。此条件下,离子液体[Bmim]BF4的收率为92.3%。该方法后处理简单,收率高,反应时间短,且采用一步法合成,简化了工艺过程和操作步骤,有利于工业化生产。 |
关键词:微波辐射; [Bmim]BF4离子液体; 一步法; 合成 |
中图分类号:O643 文献标识码:A 文章编号:1009-9212(2009)06- 0037-03 |
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One-step Synthesis of Imidazole-based Ionic Liquids under Microwave Irradiation |
SUN Meng-zhan
(Zhejiang Pharmaceutical College,Ningbo 315100, China) |
Abstract:Ionic liquid [Bmim]BF4 was synthesized from 1-methyl-1H-imidazole,1-chlorobutane and NaBF4 under microwave irradiation in a solvent free system in one step. The product was confirmed with 1H NMR and IR. The results showed the optimal reaction conditions as follows: microwave power 225 W,reaction time 15 min,n(1-chlorobutane) ∶ n(NaBF4) ∶ n(N-methylimidazolium)=1.1 ∶ 1.5 ∶ 1. The reaction afforded the product in 92.3% yield. The advantages of this process include short reaction time,simple work-up operation,low cost and easy to be scaled up. |
Key words:microwave irradiation;[Bmim]BF4 ionic liquid;one-step method;synthesis |
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作者简介:孙孟展(1981-),男,浙江宁波人,讲师,硕士,从事药物中间体的绿色合成研究。(E-mail:sunmz@mail.zjpc.net.cn)
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收稿日期:2009-10-17
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