| 第 40 卷第 1 期 |  | Vol. 40 No. 1 | | 2010 年 2 月 | Feb 2010 |
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所属栏目：农药及中间体
环丙氨嗪合成工艺研究 |
| 邱家军，单国洋，侯仲轲，熊及波，蒋狄锋，张宜仲
（浙江国邦药业有限公司，浙江 上虞，312369） |
| 摘 要：以三聚氯氰为原料经过环丙胺化和液氨氨化二步合成环丙氨嗪，总收率达88.11%。不用分离出剧毒的中间体2-环丙氨基-4，6-二氯-S-三嗪，工艺简单。在液氨氨化体系中添加溶剂乙醇，缩短了反应时间，提高了产品质量和反应收率，具有较高的工业生产价值。 |
| 关键词：三聚氯氰；环丙氨嗪；合成 |
| 中图分类号：TQ453.2 文献标识码：A 文章编号：1009-9212（2009）06- 0021-03 |
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| The Synthesis of Cyromazine |
| QIU Jia-jun，SHAN Guo-yang，HOU Zhong-ke，XIONG Ji-bo，JIANG Di-feng，ZHANG Yi-zhong
（Zhejiang Guobang Pharmaceutical Co.，Ltd，Shangyu 312369，China） |
| Abstract：Cyromazine was prepared by cyclopropylamination and amination from cyanuric chloride in total yield of 88.11%. In this process，highly toxic intermediate 2-cyclopropylamino-4，6-dichloro-s-triazine was not isolated，and ethanol was add to the reaction for decreasing the reaction time and improving the yield. The reaction conditions were optimized. The advantages of this process include short reaction time，simple work-up operation and apt to be scaled up. |
| Key words：cyanuric chloride；cyromazine；synthesis |
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作者简介：邱家军（1965-），男，江苏盐城人，高级工程师，主要从事药物合成及管理工作。
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收稿日期：2010-01-26
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