| 第 40 卷第 5 期 |  | Vol. 40 No. 5 | | 2010 年 10 月 | Oct 2010 |
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所属栏目：医药及中间体
5-溴-2-甲基苯肼盐酸盐的合成 |
| 施险峰1，詹家荣2，廖本仁1
（1.上海华谊（集团）公司技术中心 精细化工研究室，上海 200241；2.上海化学试剂研究所，上海 200333） |
| 关键词：5-溴-2-甲基苯肼盐酸盐；对甲苯胺；桑德迈尔反应；制备 |
| 中图分类号：O626 文献标识码：A 文章编号：1009-9212（2010）05-0047-02 |
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| Synthesis of 5-Bromo-2-methyl Phenylhydrazine Hydrochloride |
| SHI Xian-feng1，ZHAN Jia-rong2，LIAO Ben-ren1
（1. Technology Center of Shanghai Huayi Group，Shanghai 200241，China；2. Shanghai Chemical Reagent Research Institute，Shanghai 200233，China） |
| Abstract：A process suitable for large-scale preparation of 5-bromo-2-methyl phenylhydrazine hydrochloride was developed. The title compound was synthesized from p-toluidines via a series of reactions，including nitration，sandmeyer reaction，nitro reduction，diazotization，reduction. The product was obtained in overall yield of 30%. |
| Key words：5-bromo-2-methyl phenylhydrazine hydrochloride；p-toluidines；sandmeyer reaction；preparation |
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作者简介：施险峰（1976-），男，上海崇明人，工程师，硕士，主要从事医药中间体的研发工作。（E-mail：shixianfeng007@sina.com）
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收稿日期：2010-10-09
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