| 第 32 卷第 1 期 |  | Vol. 32 No. 1 | | 2002 年 2 月 | Feb 2002 |
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所属栏目：其它
1,2,3-三氮唑的合成工艺研究 |
| 肖国民; 杨为华; 宋文哲; 谭仁宾(东南大学化学化工系; 江苏南京) |
| 摘 要：以对甲苯磺酰肼为原料合成 1,2 ,3 三氮唑。研究了各种工艺条件对收率的影响 ,获得了较佳合成工艺 :用苯作溶剂 ,对甲苯磺酰氯与水合肼配比为 1∶2 (mol) ,在 60～ 70℃下进行缩合反应制得对甲苯磺酰肼 ,收率为 80 6% ;对甲苯磺酰肼与乙二醛以配比 1∶2 7(mol)反应后 ,通入定量的氨气进行环合反应生成 1,2 ,3 三氮唑 ,收率达 66 8% |
| 关键词：1; 2; 3三氮唑; 对甲苯磺酰肼; 合成; β内酰胺抗生素 |
| 中图分类号：TQ465 文献标识码：A 文章编号：1009-9212(2002)01-0014-02 |
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| Study on Synthesis of 1,2,3-triazole. XIAO Guo-min, et al. |
| Department of Chemistry and Chemical Engineering; Southeast University; Nanjing; 210096） |
| Abstract：Some synthetic methods of 1,2,3 triazole were introduced in this article. The process of preparation from p toluene sulfonyl hydrazine was selected for its advantages.Experiments were done to compare the different conditions of reaction, and the optimal condition to synthesis of 1,2,3 triazole was obtained as follows: p toluene sulfonyl hydrazine was prepared by reaction of MeC 6H 4SO 2Cl (a) with H 2NNH 2·H 2O(b) in presence of benzene as solvent and M ratio of a∶b=1∶2 at 60～70℃. Then high purity... |
| Key words：triazole; p toluene sulfonyl hydrazine; synthesis; β lactam antibiotics |
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收稿日期：2001-10-12
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