第 44 卷第 2 期 Vol. 44 No. 2 2014 年 4 月 Apr 2014

所属栏目：专论与综述 吡唑和1，3，4-噻二唑及硫醚（砜）抗烟草花叶病毒剂的研究进展

邝继清，吴世喜，张滕滕，张东阳，叶意强，吴志兵* （贵州大学 精细化工研究开发中心绿色农药与农业生物工程国家重点实验室培育基地，教育部绿色农药与生物工程重点实验室，贵州 贵阳 550025）

摘　要：烟草是全球最重要的经济作物之一，而我国的烟草种植面积居世界之首。当前烟草病毒病，尤其是由烟草花叶病毒引起的病害，是影响烟草正常生长的主要因素之一。综述了国内外近年来有关吡唑、1，3，4-噻二唑和硫醚（砜）类化合物在抗烟草花叶病毒活性方面的研究工作，并对其发展趋势作了展望，期望对新型高效、低毒的抗病毒剂的创制工作提供理论基础。

关键词：吡唑类；噻二唑类；硫醚（砜）类；烟草花叶病毒活性

中图分类号：TS41+1　　文献标识码：A　　文章编号：1009-9212（2014）02-0008-07

Advances in the Anti-tobacco Mosaic Virus Activities of Pyrazoles 1,3,4-Thiadiazoles and Sulfides/Sulfones

KUANG Ji-qing, WU Shi-xi, ZHANG Teng-teng, ZHANG Dong-yang, YE Yi-qiang, WU Zhi-bin* (State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Bioengineering of Ministry of Education, Center for Research & Development of Fine Chemicals, Guizhou University, Guiyang 550025, China)

Abstract：Tobacco is one of the most important economic crops in the world, and the Chinese planting area is the largest in the world. Currently, one of the main factors affecting the normal growth is caused by tobacco virus disease, especially tobacco mosaic virus. The recent research progresses on the anti-tobacco mosaic virus activities of pyrazoles, 1,3,4-thiadiazoles and sulfide (sulfone) derivatives were reviewed, and the future development trends were also presented. It is expected to provide a theoretical basis on the creative work for new, efficient and low toxicity of antiviral agents.

Key words：pyrazoles; thiadiazoles; sulfide (sulfone); tobacco mosaic virus

作者简介： 邝继清（1987-），女，海南海口人，硕士研究生，主要从事新农药与新药物设计合成（E-mail：kuangjiqing@yeah.net）。

联 系 人： 吴志兵，副教授，主要从事绿色新农药创制研究（E-mail：wzbll7l@163.com）。

收稿日期：2014-03-08