第 44 卷第 2 期 Vol. 44 No. 2 2014 年 4 月 Apr 2014

所属栏目：分析与测试 毛细管气相色谱法测定倍他米松中有机溶剂残留量

肖理红，曹远尼，胡薏冰，彭红建* （中南大学 化学化工学院， 湖南 长沙 410083）

摘　要：建立了倍他米松中溶剂残留量的分离测定方法。采用气相色谱法，以氮气为载气，FID检测器，KB-5毛细管柱，程序升温，外标法测定倍他米松中甲醇、丙酮、二氯甲烷和甲苯及N，N-二甲基甲酰胺的残留量。5种有机溶剂完全分离，在所考察的浓度范围内具有良好的线性，r=0.999 4~0.999 9，平均回收率97.48%~102.24%，精密度RSD小于5%，检测限0.03~0.10 μg／mL。所建立的方法快速、灵敏、准确，可用于倍他米松中有机溶剂残留量的测定。

关键词：倍他米松；有机溶剂残留；气相色谱

中图分类号：0657.7　　文献标识码：B　　文章编号：1009-9212（2014）02-0070-03

Determination of Residual Organic Solvents in Betamethasone by Gas Chromatography

XIAO Li-hong, CAO Yuan-ni, HU Yi-bing, PENG Hong-jian* (School of Chemistry and Chemical Engineering in Central South University, Changsha 410083, China)

Abstract：A method for determination of five residual organic solvents in betamethasone was established. All the residual solvents in betamethasone are methanol, acetone, carrene, toluene and N,N-dimethylformamide which were quantitatively determined by GC on KB-5 column with FID detector and nitrogen as the carrier. The solvents were completely separated. There was a good linearity (r=0.9994~0.9999). The RSD of precision was less than 5%. The average recovery rate was in the range of 97.4%~102.1%. The detection limit was between 0.03~0.10 μg/mL. The method is rapid, sensitive and accurate.

Key words：betamethasone; residual solvent; GC

基金项目：湖南省科技厅资助项目（2010RS4015），中南大学贵重仪器设备共享基金资助（CSUZC2014020）。

作者简介：肖理红（1975-），男，湖南湘潭人，讲师，主要从事药物化学的研究工作。

联 系 人：彭红建，副教授（E-mail：phj108@163.com）。

收稿日期： 2014-04-0