| 第 32 卷第 2 期 |  | Vol. 32 No. 2 | | 2002 年 4 月 | Apr 2002 |
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所属栏目：其它
4-氟-2-氯苯胺的合成研究 |
| 宋广亮; 朱红军; 王锦堂(南京工业大学理学院; 江苏南京) |
| 摘 要：介绍了以 4 氟苯胺为原料 ,通过乙酰化、氯代、水解三步制备 4 氟 2 氯苯胺的方法 ,对主要的影响因素作了考察并得出结论 :乙酰化反应温度应小于 30℃ ;氯代中 2 /SO2 Cl2为 1∶0 9(mol/mol)时较好 ;在水解阶段盐酸浓度控制在 4mol/L较佳 ,4 氟 2 氯苯胺的纯度大于 99% ,总收率达到 70 % |
| 关键词：氟苯胺; 乙酰化反应; 4氟2氯苯胺; 氯代 |
| 中图分类号：TQ246.3 文献标识码：A 文章编号：1009-9212(2002)02-0018-02 |
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| A Study on the Preparation of 2-Chloro-4-Fluoroaniline. |
| Song Guang liang; et al（School of Science; Nanjing University of Technology; Nanjing 210009; China） |
| Abstract：The 2 chloro 4 fluoroaniline was prepared from 4 fluoroaniline by acetylation, chlorination,hydrolysis it. The effect of the reaction conditions was also invertigated,the temperature of acetylation is lower than 30℃,mole ration of Ⅲ and SO 2Cl 2 is 1∶0.9, the HCl is 4mol/l in hydrolysis.The total yield is 70% and purity is up to 99%. |
| Key words：fluoroaniline; acetylation; 2 chloro 4 fluoroaniline; chlorination |
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收稿日期：2001-10-18
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