第 45 卷第 1 期 Vol. 45 No. 1 2015 年 2 月 Feb 2015

所属栏目：农药及中间体 2，5-二氯-4-氨基苯酚的合成

严小丽 （上海石化工业学校，上海 201512）

摘　要：以对二氯苯为原料，经硝化、水合肼催化还原、Bamberger重排等反应合成了2，5-二氯-4-氨基苯酚；并对水合肼催化还原和Bamberger重排反应的条件进行了优化。在优化的条件下，2，5-二氯苯胲的收率达96.1%，2，5-二氯-4-氨基苯酚的收率达53.1%。该合成工艺具有反应周期短、条件温和、收率高和后处理简单等优点，有产业化前景。

关键词：2，5-二氯-4-氨基苯酚；水合肼；催化还原；Bamberger重排

中图分类号：TQ460.3　　文献标识码：A　　文章编号：1009-9212（2015）01-0028-03

Synthesis of 2,5-Dichloro-4-aminophenol

YAN Xiao-li (Shanghai Petrochemical Academy, Shanghai 201512, China)

Abstract：2,5-Dichloro-4-aminophenol was synthesized using 1,4-dichlorobenzene as the starting material followed by nitration reaction, catalytic reduction with hydrazine hydrate and Bamberger rearrangement. The optimal reaction conditions for catalytic reduction with hydrazine hydrate and Bamberger rearrangement were evaluated. Under the optimal conditions, the yields of 2,5-dichlorobenzene hydroxylamine and 2,5-dichloro-4-aminophenol were 96.1% and 53.1%, respectively. The synthetic process was proved to be with many advantages including mild reaction conditions, high yield, and simple treatment for products.

Key words：2,5-Dichloro-4-aminophenol; hydrazine hydrate; catalytic reduction; Bamberger rearrangement

作者简介：严小丽（1983-），女，江苏泰州人，讲师，硕士，主要从事精细化工中间体研究（E-mail：yanxiaoli-1983@163.com）。

收稿日期： 2014-12-2