| 第 45 卷第 2 期 |  | Vol. 45 No. 2 | | 2015 年 4 月 | Apr 2015 |
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所属栏目：医药及中间体
一种2，6-二甲基苯甲酸的改进合成方法 |
| 陈 磊
（天津砚津科技有限公司，天津 300143） |
| 摘 要：以2，6-二甲基苯胺为原料，通过重氮化反应制备2，6-二甲基苯腈，经水蒸汽蒸馏法提纯后，采用75%硫酸酸化，再经酸碱法对产物进行脱色和纯化得产物2，6-二甲基苯甲酸，总收率68.4%。工艺简单、操作安全、适合工业化生产。 |
| 关键词：2，6-二甲基苯甲酸；水蒸汽蒸馏；2，6-二甲基苯腈；2，6-二甲基苯胺 |
| 中图分类号：O625.51+1 文献标识码：A 文章编号：1009-9212（2015）02-0056-02 |
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| An Efficient Method for the Preparation of 2,6-Dimethyl Benzoic Acid |
| CHEN Lei
(Tianjin Yanjin Technology Co., Ltd., Tianjin 300143, China) |
| Abstract：2,6-Dimethyl benzonitrile was synthesized by diazo reaction using 2,6-dimethyl aniline as starting material. The crude 2,6-dimethyl benzonitrile was further purified by steam distillation. The purified 2,6-dimethyl benzonitrile was acidized using 75% sulfuric acid, and the obtained crude 2,6-dimethyl benzoic acid was then decolorized and purified by acid-base method to give the target product. This simple and safe procedure is suitable for production in large scale. |
| Key words：2,6-dimethyl benzoic acid; steam distillation; 2,6-dimethyl benzonitrile; 2,6-dimethyl aniline |
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作者简介：陈 磊（1980-），男，河北唐山人，硕士，研究方向：高分子合成（E-mail：juliancl@163.com）。
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收稿日期：2015-01-31
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