第 45 卷第 3 期 Vol. 45 No. 3 2015 年 6 月 Jun 2015

所属栏目：医药及中间体 麻保沙星微囊制备方法

姜应新，郑立斌，侯仲轲，邱家军 （国邦医药化工集团有限公司，浙江 绍兴 312369）

摘　要：以辛烯基琥珀酸淀粉钠为壁材，对麻保沙星进行微囊化包埋。实验条件为n（麻保沙星）∶n（混合溶剂）=1∶9，辛烯基琥珀酸淀粉钠浓度20%，麻保沙星含量10%，真空度0.03 MPa，乳化剪切温度40℃，滴加时间60 min。所得微囊包封率99.5%。此过程操作简单，提供了麻保沙星新剂型的制备方法。

关键词：麻保沙星；微囊剂；辛烯基琥珀酸淀粉钠

中图分类号：R969　　文献标识码：A　　文章编号：1009-9212（2015）03-0014-03

Preparation of Microcapsulated Marbofloxacin

JIANG Ying-xin, ZHEN Li-bing, HOU Zhong-ke, QIU Jia-jun (Guobang Medicine and Chemical Industry Group Limited Company, Shaoxing 312369, China)

Abstract：Marbofloxacin was microencapsulated using octenylsuccinate sodium starch in this paper. The optimum experimental conditions are as following: the ratio of marbofloxacin to the mixed solvent is 1∶9; the concentration of octenylsuccinate sodium starch is 20%; the content of marbofloxacin is 10%; the vacuum is 0.03 MPa; the emulsification temperature is at 40℃; the adding period for octenylsuccinate sodium starch in dropping is 60 minutes. In a typical encapsulation process, the microencapsulated efficiency is up to 99.5%. This simple method offered a new process for the preparation of encapsulated marbofloxacin.

Key words：marbofloxacin; microcapsule; octenylsuccinate sodium starch

基金项目：国家科技部国际科技合作专项（2012DFA40940）。

作者简介：姜应新（1980-），男，黑龙江绥化人，高级工程师，博士，研究方向：药用辅料和半制剂。

收稿日期： 2015-05-1