第 31 卷第 1 期 Vol. 31 No. 1 2001 年 2 月 Feb 2001

所属栏目：其它 2-氯-4,5-二氟苯乙酮的合成及工艺研究

张翠娥; 刘鸿; 李志斌; 郑朝民;(西安近代化学研究所;)

摘　要：报道了新的医药中间体 2 氯 4 ,5 二氟苯乙酮小试和中试合成研究结果。采用邻二氟苯氯化、酰化合成工艺 ,中试放大试验氯化收率 83% ,酰化收率 86% ,精馏收率 75% ,总收率 53 5% ,产品纯度 98%以上

关键词：3; 4-二氟氯苯; 2-氯-4; 5-二氟苯乙酮; 制备;

中图分类号：TQ242.1　　文献标识码：A　　文章编号：1009-9212(2001)01-0023-03

Studies on Synthesis and Technology for 2-chrolo-4,5-difluoroacetophenone

ZHANG Cui e; LIU Hong; LI Zhi bin; ZHENG Chao min （Xi'an Morden Chemistry Research Institute; Xi'an 710065; China）;

Abstract：The synthesis of 2 chloro 4,5 difluoroacetophenone is reported. The technology of chloridization and acylation of ortho difluorobenzene is used. The chloridization yield and acylation yield is 83% and 86% respectively. The fine distillation yield is 75%, and the overall yield is 53.5%. The purity of product is over 98%.

Key words：3; 4difluorochlorobenzene; 2 chloro 4; 5 difluoroacetophenone; preparation;

收稿日期：2000-09-12

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