| 第 46 卷第 1 期 |  | Vol. 46 No. 1 | | 2016 年 2 月 | Feb 2016 |
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所属栏目：专论与综述
2-吲哚酮类化合物的研究进展 |
| 张和智，欧阳贵平*，陈 洪，张 苈，王圆圆
（贵州大学 精细化工研究开发中心，贵州 贵阳 550025） |
| 摘 要：2-吲哚酮类化合物具有抗炎、抗精神病、抗癌、抗菌等生物活性，特别是其手性合成的螺吲哚酮类化合物的生物活性和药效研究是当前的研究热点。结合部分已上市和临床研究的药物，对近年来2-吲哚酮类化合物的衍生合成及其研究进展进行了综述。 |
| 关键词：2-吲哚酮；手性合成；螺吲哚酮 |
| 中图分类号：O626 文献标识码：A 文章编号：1009-9212（2016）01-0009-08 |
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| Review of Oxindole Compounds Studies |
| ZHANG He-zhi, OUYANG Gui-ping*, CHEN Hong, ZHANG Li, WANG Yuan-yuan
(Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang 550025, China) |
| Abstract：Oxindole compounds have anti-inflammatory, anti-psychotic, anti-cancer, anti-bacterial and other biological activities. Especially biological activity and efficacy study of its Chiral Synthesis-Spirooxindoles remains a hot research spot at present. The paper mainly reviews recent studies of derived synthesis of indolinones and its present research achievements based on studies of drugs which have been listed and those under clinical trial or those have been subjected to it. |
| Key words：oxindole; chiral synthesis; spirooxindoles |
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作者简介：张和智（1988 -），男，贵州石阡人，硕士研究生，研究方向：精细有机合成（E-mail：earth.zhang@163.com）。
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联 系 人： 欧阳贵平，教授，研究方向：杂环化学（E-mail：oygp710@163.com）。
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收稿日期：2016-01-04
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