| 第 46 卷第 5 期 |  | Vol. 46 No. 5 | | 2016 年 10 月 | Oct 2016 |
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所属栏目：医药及中间体
3，4-二羟基苯乙酮的合成 |
| 丁华琴，张玉娇，蒋旭亮*
（沈阳药科大学 制药工程学院，辽宁 沈阳 110016） |
| 摘 要：研究了邻苯二酚在不同条件下的Friedel-Crafts乙酰化反应。利用三氟化硼乙醚溶液作催化剂，乙酸为乙酰化试剂，合成了3，4-二羟基苯乙酮，并在此基础上，进一步对反应条件进行了优化。优化的条件为：n（三氟化硼）∶n（邻苯二酚）=1.2∶1.0，反应温度为80℃，反应时间为4 h，优化条件下，3，4-二羟基苯乙酮的收率达66.7%。 |
| 关键词：3，4-二羟基苯乙酮；三氟化硼；乙酸；乙酰化反应 |
| 中图分类号：O625.42 文献标识码：A 文章编号：1009-9212（2016）05-0025-02 |
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| Synthesis of 3,4-Dihydroxyacetophenone |
| DING Hua-qin, ZHANG Yu-jiao, JIANG Xu-liang*
(College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China) |
| Abstract：Friedel-Crafts acetylation reaction of catechol under different conditions was studied. 3,4-Dihydroxyacetophenone was synthesized using boron trifluoride/ethyl ether solution as catalyst and acetic acid as acetylation reagent, and the reaction conditions were further optimized. The optimized reaction conditions were as following: the molar ratio of BF3 to catechol was of 1.2; and the reaction temperature and time were 80℃ and 4 h, respectively. Under the optimized conditions, 3,4-dihydroxyacetophenone was obtained with a yield of 66.7%. |
| Key words：3,4-dihydroxyacetophenone; boron trifluoride; acetic acid; acetylation reaction |
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作者简介：丁华琴（1992-），女，江苏东台人，硕士研究生，研究方向：抗肿瘤药物的开发与研究。
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联 系 人： 蒋旭亮，副教授，研究方向：新药的设计、合成与活性研究（E-mail：xuliangjiang1975@163.com）。
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收稿日期：2016-09-26
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