第 47 卷第 2 期 | ![](image2/wentou.gif) | Vol. 47 No. 2 | 2017 年 4 月 | Apr 2017 |
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所属栏目:有机合成原料
响应面法优化二甲基砜的制备工艺 |
郭香琴1,2,周石洋1,2,杨善彬1,2*
(1.重庆师范大学 化学学院 重庆 401331;2.重庆师范大学 活性物质生物技术教育部工程研究中心 重庆401331) |
摘 要:以二甲基亚砜与过氧化氢为原料制备了二甲基砜。在单因素实验基础上,运用响应面法,以二甲基砜的收率为响应值,通过回归分析得出制备二甲基砜的优化条件为:反应温度95.7℃,反应时间1.57 h,v(二甲基亚砜)∶v(过氧化氢)=1.0∶1.1,过氧化氢的滴加速度4 mL/min。在此条件下二甲基砜的收率为88.6%。 |
关键词:二甲基亚砜;二甲基砜;响应面法 |
中图分类号:TQ247.3 文献标识码:A 文章编号:1009-9212(2017)02-0055-05 |
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Preparation of Methylsulfonylmethane via Response Surface Methodology |
GUO Xiang-qin1,2, ZHOU Shi-yang1,2, YANG Shan-bin1,2*
(1.College of Chemistry, Chongqing Normal University, Chongqing 401331, China; 2. Engineering Research Center of Biotechnology of Active Substances Ministry of Education) in Chongqing Normal University, Chongqing 401331, China) |
Abstract:This paper presented the progress in the preparation of methylsulfonylmethane using DMSO and H2O2. Based on the single-factor experiments, response surface methodology(RSM) was used to explore the optimal conditions for preparing methylsulfonylmethane and the relationship between preparation parameters and yield using regression analysis. The optimum conditions were as following: reaction temperature was of 95.7℃; reaction time was of 1.57 h; volume ratio of H2O2 to DMSO was of 1.1∶1; the velocity of H2O2 was of 4 mL/min. The yield of methylsulfonylmethane was up to 88.6%. |
Key words:DMSO; methylsulfonylmethane; response surface methodology |
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基金项目:重庆市社会民生科技创新专项(cstc2015shmszx80060),活性物质生物技术教育部工程研究中心开放基金(20150408),重庆师范大学博士启动项目(12XLB006)。
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作者简介:郭香琴(1991-),女,重庆人,硕士研究生,研究方向:化学工程(E-mail:1072271995@qq.com)。
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联 系 人:杨善彬,教授,博士。
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收稿日期: 2017-03-1
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