| 第 47 卷第 6 期 |  | Vol. 47 No. 6 | | 2017 年 12 月 | Dec 2017 |
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所属栏目：专论与综述
α-羟基取代双膦酸类化合物的合成研究进展 |
| 肖 灿
（扬子江药业集团有限公司 新药研究院，江苏 泰州 225321） |
| 摘 要：α-羟基取代双膦酸类化合物为双膦酸类骨吸收抑制剂，在临床上用以治疗以骨质疏松症为代表的骨代谢疾病，有着良好的临床应用价值和广阔的市场前景。按起始物料的不同将合成方法分成了3类。论述了优点和缺点，对其合成研究进展进行了综述。 |
| 关键词：α-羟基取代双膦酸；骨质疏松症；合成；研究进展 |
| 中图分类号：O627.51 文献标识码：B 文章编号：1009-9212（2017）06-0006-04 |
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| Progress in Synthesis of α-Hydroxy Substituted Bisphosphonic Acid Analogues |
| XIAO Can
(Jiangsu (YRPG) New Medicine Research Institute, Yangtze River Pharmaceutical Group, Taizhou 225321, China) |
| Abstract：α-Hydroxy substituted bisphosphonic acid analogues are bisphosphonate bone resorption inhibitors, and are clinically used to treat bone metabolic diseases such as osteoporosis. These analogues have good clinical value and broad market prospect. These methods were categorized into three classes based on starting materials. The merits and disadvantages of these routes were discussed, and progress in synthesis was reviewed. |
| Key words：α-hydroxyl substituted bisphosphonic acid; osteoporosis; synthesis; progress |
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作者简介：肖 灿（1984-），男，四川达州人，工程师，硕士，主要从事化学原料药的合成及工艺开发（E-mail：livexc@163.com）。
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收稿日期：2017-12-10
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