| 第 48 卷第 3 期 |  | Vol. 48 No. 3 | | 2018 年 6 月 | Jun 2018 |
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所属栏目：医药及中间体
溴代丙酮酸的合成新工艺 |
| 黄子涵1，邵国光1*，胡 能2
（1. 长沙市第二十一中学，湖南 长沙 410000；2. 长沙理工大学 化学与生物工程学院，湖南 长沙 410114） |
| 摘 要：以丙酮酸和二溴海因为原料制备了溴代丙酮酸。优化工艺条件为：反应温度为50℃，催化剂为对甲苯磺酸，溶剂为甲醇，收率为40%。该新工艺具有操作友好、后处理简单等优势。 |
| 关键词：丙酮酸；二溴海因；溴代丙酮酸 |
| 中图分类号：O632 文献标识码：A 文章编号：1009-9212（2018）03-0031-02 |
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| A Novel Synthetic Process for the Preperation of Brominated Pyruvic Acid |
| HUANG Zi-han1, SHAO Guo-guang1*, HU Neng2
(1. NO. 21 Middle School of Changsha, Changsha 410000, China; 2. Changsha University of Science and Engineering, College of Chemical and Biological Engineering, Changsha 410114, China) |
| Abstract：Brominated pyruvic acid is an important intermediate, which is synthesized using pyruvic acid and dibromohydantoin as the raw materials. The yield of brominated pyruvic acid is of 40% under the optimum conditions including reaction temperature of 50℃, p-toluene sulphonic acid as catalyst, and methanol as solvent. This novel process has advantages of friendly operation and simple post-processing. |
| Key words：pyruvic acid; dibromohydantoin; brominated pyruvic acid |
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作者简介：黄子涵（2001-），男，湖南长沙人。
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联 系 人：邵国光，特级教师，从事化学教育研究（E-mail：shao631226@126.com）。
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收稿日期：2018-05-20
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