| 第 48 卷第 5 期 |  | Vol. 48 No. 5 | | 2018 年 10 月 | Oct 2018 |
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所属栏目：医药及中间体
微波技术下肉桂酸合成工艺研究 |
| 蔡旭婷，毛琳怡，张鑫伟，李晨帆，胡鸿雨*
（浙江师范大学 行知学院，浙江 金华 321004） |
| 摘 要：微波辐射下，以无水碳酸钾作为催化剂，苯甲醛、乙酸酐为原料合成肉桂酸。采用1H NMR对产物进行表征。考察了辐射功率、辐射时间、催化剂的用量对肉桂酸收率的影响。优化反应条件为，辐射功率450 W，辐射时间30 min，无水碳酸钾用量为8%。优化条件下，收率达70.0%以上。 |
| 关键词：肉桂酸；微波辐射；催化合成 |
| 中图分类号：O621.25 文献标识码：A 文章编号：1009-9212（2018）05-0022-03 |
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| Application of Microwave Technology in the Synthesis of Cinnamic Acid |
| CAI Xu-ting, MAO Lin-yi , ZHANG Xin-wei, LI Chen-fan1, HU Hong-yu*
(Xingzhi College of Zhejiang Normal University, Jinhua 321004, China) |
| Abstract：Cinnamic acid was synthesized from the reaction of benzaldehyde with acetic anhydride using anhydrous potassium carbonate as catalyst under microwave irradiation. The products were characterized by 1H NMR. The effects of factors including radiation power, radiation time and amount of catalyst on the yield of cinnamic acid were investigated. The results showed that the optimum reaction conditions were as the following: radiation power of 450 W; radiation time of 30 min; dosage of anhydrous potassium carbonate of 8%, and yield was over 70.0%. |
| Key words：cinnamic acid; microwave radiation; catalyzed synthesis |
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基金项目：浙江师范大学实验技术开发资助项目（SJ201824），浙江省高校实验室工作研究项目（ZD201813）。
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作者简介：蔡旭婷（1998-），女，浙江东阳人，主要从事有机合成研究。
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联 系 人：胡鸿雨，主要从事有机合成研究工作（E-mail：huhongyu22@126.com）。
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收稿日期：2018-08-09
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