| 第 49 卷第 4 期 |  | Vol. 49 No. 4 | | 2019 年 8 月 | Aug 2019 |
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所属栏目：农药及中间体
微通道反应器法合成1-乙酰基-1-氯环丙烷的工艺优化初探 |
| 杨丙连，王建博
（上海泰禾国际贸易有限公司 技术中心，上海 200335） |
| 摘 要：以3，5-二氯-2-戊酮为原料，在相转移催化剂存在的条件下，在微通道反应器中连续反应制备1-乙酰基-1-氯环丙烷。对催化剂、液碱用量、反应温度以及流速条件等进行优化。优化的工艺条件为：反应温度80℃，3，5-二氯-2-戊酮进料流速50 mL·min-1，苄基三乙基氯化铵为催化剂，n（碱）∶n（苄基三乙基氯化铵）∶n（3，5-二氯-2-戊酮）=1.20∶0.02∶1.00，优化条件下，收率可达81.96%。 |
| 关键词：1-氯-1-乙酰基环丙烷；微通道反应器；工艺优化 |
| 中图分类号：S482.2 文献标识码：A 文章编号：1009-9212（2019）04-0017-03 |
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| Synthesis of 1-Acetyl-1-chlorocyclopropane Using Microchannel Reactor |
| YANG Bing-lian,WANG Jia-bo
(R&D Center of CAC Shanghai International Trading Co.,Ltd., Shanghai 200335, China) |
| Abstract：3,5-Dichloro-2-pentanone as a raw material, under phase transfer catalyst, 1-acetyl-1-chlorocyclopropane was prepared by continuously reacting in a microchannel reactor. The catalyst, liquid base, reaction temperature and flow rate were optimized. The preferred process conditions were as follows: reaction temperature was 80℃, 3,5-dichloro-2-pentanone feed flow rate was of 50 mL·min-1; benzyl triethyl ammonium chloride was used as catalyst, n(sodium hydroxide) ∶ n(benzyl triethyl ammonium chloride) ∶ n(3,5-dichloro-2-pentanone) was of 1.20 ∶ 0.02 ∶ 1.00. Under these conditions the yield was up to 81.96%. |
| Key words：1-chloro-1-acetylcyclopropane; microchannel reactor; process optimization |
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作者简介：杨丙连（1984-），男，安徽萧县人，工程师，硕士研究生，主要从事农药及中间体合成工艺技术开发（E-mail：bingliany@126.com）
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收稿日期：2019-07-31
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