第 49 卷第 5 期 Vol. 49 No. 5 2019 年 10 月 Oct 2019

所属栏目：农药及中间体 基于正交试验优化研究乙草胺通氨醇解工艺

陈朋朋，胡先明，蒋慧华，王 雨 （江苏莱科作物保护有限公司，江苏　南通　226400）

摘　要：对乙草胺的合成工艺路线进行了研究。通过对乙草胺通氨醇解工段：2-甲基-6-乙基-N-氯甲基-α-氯乙酰苯胺加入乙醇后醇解、通氨合成乙草胺进行正交试验，确定了溶剂加入量为1∶3、醇解温度为35℃、醇解时间为4 h、通氨温度为20℃、终点pH值为8时，反应单步收率达98.5%。后处理后产品的含量和色泽在国内同行均处于领先水平。

关键词：乙草胺；合成；正交试验；工艺优化

中图分类号：TQ455　　文献标识码：A　　文章编号：1009-9212（2019）05-0015-04

Study on the Process of Inducing Ammonia into Acetochlor and the Alcoholysis Reaction Based on Orthogonal Experiment Test

CHEN Peng-peng, HU Xian-ming, JIANG Hui-hua, WANG Yu (Jiangsu Laike Crop Protection Co.,Ltd., Nantong 226400, China)

Abstract：This article reported a research on the synthesis of acetochlor. Through the orthogonal experiment test on inducing ammonia into acetochlor and the alcoholysis reaction by adding 2-methyl-6-ethyl-N-chloromethyl-α-acetylchloroaniline to ethyl alcohol, the conditons of orthogonal test were obtained as followings: the proprtion of the solvent was of 1∶3, the temperature of the alcoholysis reaction was of 35℃, the reaction time was of 4 hours, the temperature of adding ammonia was of 20℃and the pH value was of 8. The yield of single-step reaction of acetochlor was above 98.5%. After this orthogonal experiment, the quality and appearance of the products are ranking the top of the industry.

Key words：acetochlor; synthesis; orthogonal test; process optimization

作者简介：陈朋朋（1986-），男，江苏南通人，工程师，研究方向：化工技术的研究与开发。

收稿日期：2019-05-23