| 第 50 卷第 3 期 |  | Vol. 50 No. 3 | | 2020 年 6 月 | Jun 2020 |
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所属栏目：医药及中间体
联苯乙酸的合成工艺改进 |
| 任业明，邓玉晓，马新成，赵思太*，刘宜辉，段崇刚，孙晋瑞
（山东省药学科学院 山东省化学药物重点实验室，山东 济南 250101） |
| 摘 要：以联苯为原料，经傅克酰基化、缩合、皂化、酸化等步骤制得联苯乙酸，总收率79.3%，产品纯度>99.95%，其结构经MS、1H NMR确证。对关键中间体联苯乙酮的合成工艺进行了改进，减少副反应，提高其纯度。 |
| 关键词：联苯；联苯乙酮；合成 |
| 中图分类号：TQ24 文献标识码：A 文章编号：1009-9212（2020）03-0044-03 |
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| Improvement of Synthetic Route for Biphenylacetic Acid |
| REN Ye-ming, DENG Yu-xiao, MA Xin-cheng, ZHAO Si-tai*, LIU Yi-hui, DUAN Chong-gang, SUN Jin-rui
(Shandong Provincial Key Laboratory of Chemical Drugs, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China) |
| Abstract：Diphenylacetic acid was prepared through a series reactions including Friedel-crafts acylation, condensation, saponification and acidification using biphenyl as the starting material. The total yield was 79.3%, and the purity of the product was more than 99.95%. Its structure was confirmed by MS and 1H NMR. The synthesis process of key intermediate acetophenone was improved to reduce side reactions and improve its purity |
| Key words：biphenyl; benzophenone; synthesis |
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作者简介：任业明（1979-），男，山东济南人，工程师，研究方向：药物合成研究（E-mail：522986483@qq.com）。
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联 系 人：赵思太，高级工程师，研究方向：药物合成研究（E-mail：79079189@qq.com）。
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收稿日期：2020-04-25
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