第 50 卷第 5 期 Vol. 50 No. 5 2020 年 10 月 Oct 2020

所属栏目：农药及中间体 环保型杀菌剂啶酰菌胺的合成

尚 宇 ，李 飞，郭亚飞 （陕西省环境监测中心站，陕西 西安 710054）

摘　要：研究了一种合成环保型杀菌剂啶酰菌胺的方法，并优化其合成工艺。以邻氯硝基苯和4-氯苯硼酸为原料，经过Suzuki偶联、还原、缩合3步反应合成啶酰菌胺。在优化的反应条件下，3步总收率≥43%（以邻氯硝基苯计），产物纯度98%；产物结构经IR、1H NMR、MS确证。第1步Suzuki偶联反应中，优化的反应条件是无水碳酸钾作碱，催化剂四（三苯基膦）钯的用量为15%（以邻氯硝基苯计）。第2步还原反应温度为50 ℃。该工艺简单经济，条件温和，绿色环保。

关键词：环保；杀菌剂；啶酰菌胺；合成

中图分类号：S482.2　　文献标识码：A　　文章编号：1009-9212（2020）05-0012-04

Green Synthesis of A New Environmental Friendly Fungicide Boscalid

SHANG Yu, LI Fei, GUO Ya-fei (Shaanxi Environmental Monitoring Center, Xi'an 710054, China)

Abstract：A method for the synthesis of fungicide boscalid, a new environmental friendly bactericide was studied and the synthetic process was further optimized. Boscalid was prepared using 1-chloro-2-nitrobenzene and 4-chlorophenylboronic acid as starting materials through a series of reactions including Suzuki coupling reaction, reduction and condensation. Under the optimal reaction conditions, the total yield of boscalid was over 43% based on 1-chloro-2-nitrobenzene with a purity of 98%. The structure was confirmed by IR, 1H NMR, MS. In the first step, K2CO3 being used as alkali, 15% of catalyst Pd(PPh3)4 based on 1-chloro-2-nitrobenzen was used as the optimized condition. The optimal reaction temperature of the second reduction reaction is 50 ℃. This process is simple, mild, economical, and environmental friendly.

Key words：environmental friendly; boscalid; fungicide; synthesis

作者简介：尚 宇（1983—），男，辽宁抚顺人，工程师，主要从事环境监测工作（E-mail：523588666@qq.com）。

收稿日期：2020-07-31