| 第 50 卷第 5 期 |  | Vol. 50 No. 5 | | 2020 年 10 月 | Oct 2020 |
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所属栏目：医药及中间体
脱氢枞基酰基吡唑化合物的合成与表征 |
| 伍 勇，黄春花，徐 静
（四川卫生康复职业学院 药学系，四川 自贡 643000） |
| 摘 要：以脱氢枞酸为原料，在二氯甲烷溶剂中与二氯亚砜酰化合成脱氢枞酰氯（2）；无水碳酸钠作缚酸剂，脱氢枞酰氯（2）与80%水合肼在四氢呋喃溶剂中，常温条件下生成脱氢枞酰肼（3）；脱氢枞酰肼（3）与乙酰丙酮经三乙胺催化，在N，N-二甲基甲酰胺溶剂中回流8 h，最终脱水成环生成脱氢枞基酰基吡唑化合物（1），收率43.3％。产物结构经核磁共振氢谱、碳谱及红外光谱确证。 |
| 关键词：脱氢枞酸；吡唑；合成 |
| 中图分类号：TQ252.1 文献标识码：A 文章编号：1009-9212（2020）05-0021-03 |
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| Synthesis and Characterization of Dehydroabietyl Pyrazole Compound |
| WU Yong, HUANG Chun-hua, XU Jing
(Department of Pharmacy, Sichuan Vocational College of Health and Rehabilitation, Zigong 643000, China) |
| Abstract：Using dehydroabietic acid as raw material, dehydroabietic acid chloride (1) was synthesized in methylene chloride solvent with thionyl chloride; and then, anhydrous sodium carbonate as acid binding agent, dehydroabietic hydrazide (2) was prepared from product 1and 80% hydrazine hydrate in tetrahydrofuran solvent normal temperature conditions; the last, dehydroabietyl pyrazole compound(3), in yield of 43.3%, was obtained from product 2 and acetylacetone, which were catalyzed by triethylamine and were refluxed in N,N-dimethylformamide solvent for 8 hours; the product structure was characterized by IR, 1H NMR and 13C NMR. |
| Key words：dehydroabietic acid; pyrazole; synthesis |
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基金项目：自贡市重点科技计划资助项目（2018CZ30），四川卫生康复职业学院重点项目（CWKY-2018Z-03）。
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作者简介：伍 勇（1975—），男，四川荣县人，副教授，硕士，主要从事天然产物化学研究（E-mail：wuyongrx@163.com）。
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收稿日期： 2020-10-1
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