| 第 50 卷第 6 期 |  | Vol. 50 No. 6 | | 2020 年 12 月 | Dec 2020 |
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所属栏目：专论与综述
二苯氯甲烷的制备方法及在药物合成中的应用 |
| 闫小玉，温锦荣，刘艳丽，汤晓琴，全 杰，张曼玲，邓护军，门 靖
（西安万隆制药股份有限公司，陕西 西安 710119） |
| 摘 要：二苯氯甲烷是一种应用前景广阔的医药中间体。综述了二苯氯甲烷的合成方法，分析比较了光化学合成法、三光气合成法、盐酸氯化合成法三种路线的优势与不足。同时归纳了二苯氯甲烷在中枢神经兴奋药物、组胺H1受体拮抗剂、新型组蛋白去乙酰化酶抑制剂药物合成中的应用现状，对二苯氯甲烷在药物设计及合成领域具有借鉴意义。 |
| 关键词：二苯氯甲烷；莫达非尼；奥沙米特；组蛋白去乙酰化酶抑制剂 |
| 中图分类号：R914 文献标识码：B 文章编号：1009-9212（2020）06-0007-03 |
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| The Preparation of Chlorodiphenylmethane and Its Application in Drug Synthesis |
| YAN Xiao-yu, WEN Jin-rong, LIU Yan-li, TANG Xiao-qin, QUAN Jie, ZHANG Man-ling, DENG Hu-jun, MEN Jing
（Xi'an WanLong Pharmaceutical Co., Ltd., Xi'an 710119, China） |
| Abstract：Chlorodiphenylmethane is an active pharmaceutical intermediate with strong application prospects. In this paper, the synthesis methods of chlorodiphenylmethane were reviewed. The advantages and disadvantages of methods including photochemical synthesis, triphosgene synthesis and hydrochloric acid chlorination synthesis were analyzed and compared. The application status of chlorodiphenylmethane in the synthesis of central nervous stimulants, histamine H1 receptor antagonists, novel histone deacetylase inhibitors drug synthesis were also summarized with reference significance for chlorodiphenylmethane in the field of drug synthesis. |
| Key words：chlorodiphenylmethane; modafinil; oxatomide; histone deacetylase inhibitor |
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作者简介：闫小玉（1987—），女，内蒙古赤峰人，硕士，主要从事药品质量研究、检测方法开发及申报资料撰写工作。
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联 系 人：门 靖，高级工程师，硕士，主要从事医药研发、原料药技术转移及申报资料撰写工作（E-mail：1257391857@qq.com）。
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收稿日期：2020-08-14
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