第 51 卷第 1 期Vol. 51 No. 1
2021 年 2 月Feb 2021
所属栏目：功能材料

印迹材料MIP-PAM／PSA的制备及对氧氟沙星的识别与拆分
胡译之，李延斌*，何红芳，唐风娣，门吉英 （中北大学 化学系，山西 太原 030051）
摘　要：通过接枝聚合和交联印迹过程同步法，以伯胺树脂微球（PSA）为基质，S-氧氟沙星为模板分子，乙二醇二缩甘油醚（EGDE）为交联剂，制备了S-氧氟沙星的表面分子印迹材料MIP-PAM／PSA。研究了分子印迹材料MIP-PAM／PSA对氧氟沙星对映体拆分的可行性。采用FTIR、SEM对PSA和印迹材料的结构、形貌进行了表征。结果表明，PSA微球表面出现了印迹空穴，成功制备出了印迹材料MIP-PAM／PSA。等温结合性能测定表明，印迹材料MIP-PAM／PSA对S-氧氟沙星具有良好的识别选择性。印迹材料对R-氧氟沙星的分配系数为206.1 mL·g-1，对S-氧氟沙星的分配系数为694.1 mL·g-1，S-氧氟沙星相对于R-氧氟沙星识别选择性系数为3.37，表现出良好的拆分性能。此外，印迹材料MIP-PAM／PSA具有良好的解吸性能，解吸率达到99.5%。
关键词：表面分子印迹；伯胺树脂球；氧氟沙星；识别选择性；手性拆分
中图分类号：TQ31　　文献标识码：A　　文章编号：1009-9212（2021）01-0023-07
Preparation of MIP-PAM /PSA as Imprinting Material and Its Application in the Identification and Resolution of Ofloxacin
HU Yi-zhi, LI Yan-bin*, HE Hong-fang, TANG Feng-di, MEN Ji-ying (Department of Chemistry, North University, Taiyuan 030051, China)
Abstract：MIP-PAM/PSA, the surface imprinted material of S-ofloxacin, was prepared using primary amine resin microspheres (PSA) as matrix, S-ofloxacin as template molecule and glycol diglycidyl ether (EGDE) as the cross-linking agent through a synchronization process including cross-linking polymerization and imprinting process. Then, the performance of feasibility of MIP-PAM/PSA for the separation of ofloxacin enantiomers was studied. The structure and morphology of PSA and MIP-PAM/PSA were characterized using FTIR, Raman spectroscopy and SEM. The experimental results showed that imprinted holes on the surface of PSA microsphere was obtained. The isothermal binding property testing results showed that MIP-PAM/PSA had good selectivity for S-ofloxacin recognition. The distribution coefficients of R-ofloxacin and S-ofloxacin for the imprinted materials were 206.1 mL·g-1 and 694.1 mL·g-1, respectively. The recognition selectivity coefficient of S-ofloxacin compared to R-ofloxacin was 3.37, showing good resolution performance. In addition, this imprinted material MIP-PAM/PSA had a good desorption performance with a desorption rate of 99.5%.
Key words：surface molecular imprinting; primary amine resin ball; ofloxacin; identify selectivity; chiral resolution
基金项目：国家自然科学基金资助项目（21805249）。
作者简介：胡译之（1996—）女，山西忻州人，硕士研究生，研究方向：分子印迹材料（E-mail：635093996@qq.com）。
联 系 人：李延斌，副教授，博士（E-mail：lyb2010@nuc.edu.cn）。
收稿日期：2021-01-03