第 51 卷第 2 期 Vol. 51 No. 2 2021 年 4 月 Apr 2021

所属栏目：专论与综述 4′-羟基联苯-4-甲酸合成工艺研究进展

马利娟，邓 博 （西安万隆制药股份有限公司，陕西 西安 710119）

摘　要：综述了以4-羟基联苯、4-羟基-4′-氰基联苯、4-羧基苯硼酸、4-羟基苯硼酸为原料制备4′-羟基联苯-4-甲酸的四种合成方法，对每种合成工艺的优缺点进行分析，并介绍了其在构筑有机发光材料、液晶材料及其中间体、法尼醇X受体拮抗剂等领域合成中的应用，展望了4′-羟基联苯-4-甲酸的应用前景。

关键词：4′-羟基联苯-4-甲酸；合成工艺；曲法罗汀

中图分类号：O634　　文献标识码：B　　文章编号：1009-9212（2021）02-0015-05

4'-Hydroxy-4-biphenylcarboxylic Acid

MA Li-juan，DENG Bo (Xi'an WanLong Pharmaceutical Co.,Ltd., Xi'an 710119,China)

Abstract：According to the different starting materials, the synthetic methods from 4-hydroxybiphenyl, 4-hydroxy-4'- cyanobiphenyl, 4-carboxyphenylboronic acid and 4-hydroxyphenylboronic acid were reviewed. The advantages and disadvantages of each synthesis process were discussed. Meanwhile the application status of 4'-hydroxy-4-biphenylcarboxylic acid in organic luminescent materials, liquid crystal materials and their intermediates, farnesoid X receptor antagonists were summarized. At the same time, the future application was prospected.

Key words：4'-hydroxy-4-biphenylcarboxylic acid; synthesis process; trifarotene

作者简介：马利娟（1983—），女，陕西西安人，主管药师，执业药师，主要从事原料药研发与项目立项、制剂开发及药品注册工作。

收稿日期：2021-01-20