µÚ 52 ¾íµÚ 2 ÆÚ | ![](image2/wentou.gif) | Vol. 52 No. 2 | 2022 Äê 4 Ô | Apr 2022 |
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Synthesis and Characterization of Aldoxime |
WANG Ying1, XU Xiao-na1, MA Hong-zhu2
(1. School of Pharmaceutical & Chemical Engineering, Xianyang Vocational Technical College, Xianyang 712000, China; 2. School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China) |
Abstract£ºA series of aldoxime compounds 1a~1o were prepared from the reaction of aldehydes 2a~2o with hydroxylamine hydrochloride. Among them, 1d, 1e, 1f, 1j, 1l and 1o are new compounds. The structures of the products were characterized by 1H NMR and ESI-MS. The effect of reaction conditions on the yield of product 1a was investigated as model reaction. The optimal synthesis conditions of compound 1a were as followings: the material ratio of n(hydroxylamine hydrochloride)¡Ãn(2a) = 1.2¡Ã1.0, the reaction mixture was stirred in methanol for 5 min at 25 ¡æ; the yield of 2-nitrobenzaldehyde oxime (1a) was up to 90.8 % under the optimal reaction conditions. |
Key words£ºaldoxime; synthetic process; structural characterization |
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ÊÕ¸åÈÕÆÚ£º2022-01-01
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