第 52 卷第 2 期 Vol. 52 No. 2 2022 年 4 月 Apr 2022

所属栏目：有机合成原料 醛肟的合成及表征研究

王 莹1, 徐小娜1, 马红竹2 （1. 咸阳职业技术学院 医药化工学院，陕西 咸阳 712000；2. 陕西师范大学 化学化工学院，陕西 西安 710119）

摘　要：以醛2a~2o为原料，分别与盐酸羟胺反应得到了醛肟1a~1o，其中新化合物六种（1d、1e、1f、1j、1l、1o）产物结构经1H NMR和ESI-MS表征确证。并以2-硝基苯甲醛肟（1a）的合成为例，考察了影响反应的主要因素，确定醛肟的合成条件为：物料比n（盐酸羟胺）∶n（2a）=1.2∶1.0，反应溶剂为甲醇，25 ℃反应5 min。在该条件下，2-硝基苯甲醛肟（1a）收率为90.8 %。

关键词：醛肟；合成工艺；结构表征

中图分类号：TQ463　　文献标识码：A　　文章编号：1009-9212（2022）02-0036-03

Synthesis and Characterization of Aldoxime

WANG Ying1, XU Xiao-na1, MA Hong-zhu2 (1. School of Pharmaceutical & Chemical Engineering, Xianyang Vocational Technical College, Xianyang 712000, China; 2. School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China)

Abstract：A series of aldoxime compounds 1a~1o were prepared from the reaction of aldehydes 2a~2o with hydroxylamine hydrochloride. Among them, 1d, 1e, 1f, 1j, 1l and 1o are new compounds. The structures of the products were characterized by 1H NMR and ESI-MS. The effect of reaction conditions on the yield of product 1a was investigated as model reaction. The optimal synthesis conditions of compound 1a were as followings: the material ratio of n(hydroxylamine hydrochloride)∶n(2a) = 1.2∶1.0, the reaction mixture was stirred in methanol for 5 min at 25 ℃; the yield of 2-nitrobenzaldehyde oxime (1a) was up to 90.8 % under the optimal reaction conditions.

Key words：aldoxime; synthetic process; structural characterization

作者简介：王 莹（1977—），女，陕西眉县人，副教授，硕士，研究方向：有机合成化学、催化化学（E-mail:ppsurre@163.com）。

收稿日期：2022-01-01