第 32 卷第 6 期 Vol. 32 No. 6 2002 年 12 月 Dec 2002

所属栏目：其它 2-氨基-5-(N,N-二异丙基)氨基-1,3,4-噻二唑的合成研究

叶余原; 童国通; 潘富友(台州学院化学系; 杭州电化集团有限公司研发中心; 浙江台州; 317000; 浙江杭州; 310053)

摘　要：以氨基硫脲和甲酸为原料经一步法缩合环化合成了 2 氨基 1,3,4 噻二唑 ,再经溴化、胺化制得目标产物 ,产品总收率 6 0 %。研究了反应的影响因素 ,评估和优化了工艺参数 ;此法原料易得 ,便于生产。

关键词：2氨基5（N; N二异丙基）氨基1; 3; 4噻二唑; 2氨基1; 缩合环化; 溴化; 胺化

中图分类号：TQ252.5　　文献标识码：A　　文章编号：1009-9212(2002)06-0027-02

Synthesis of 2-Amino-5-(N,N-diisopropyl)amino-l, 3,4-thiadi-azole

YE Yu-yuan; et al . （ Department of Chemistry; Taizhou College; Taizhou Zhejiattg; 317000; China）2-mino-5-（N; N-diisopropyl ）

Abstract：amino-1 , 3, 4-thiadiazole was synthesized using aminothiourea and formic acid as raw materials through cyclocondensation, bromation and animation. The factors influencing the reactions were investigated. The overall yield was 60% , the purity of the product was over 99% . The optimum condition of synthesis was established.

Key words：Amino-5-（ N; N-diisopropyl） amino-1; 3; 4-thiadiazole; 2-Amino-l; cyclocondensation; bromation; amination

收稿日期：2002-08-21

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