第 52 卷第 4 期 Vol. 52 No. 4 2022 年 8 月 Aug 2022

所属栏目：功能材料 N-（4-乙氧基羰基苯基）-N-甲基-N-苯基甲脒的合成

刘 柳，孟纪文 （中昊（大连）化工研究设计院有限公司，辽宁 大连 116023）

摘　要：以4-氨基苯甲酸乙酯、原甲酸三甲酯、N-甲基苯胺为原料，活性Al2O3为催化剂，一步合成了N-（4-乙氧基羰基苯基）-N'-甲基-N'-苯基甲脒。考察了原料配比、催化剂种类、温度和时间对反应的影响。优化的工艺条件为：n（对氨基苯甲酸乙酯）∶n（原甲酸三甲酯）∶n（N-甲基苯胺）=1.00∶1.10∶1.05，活性Al2O3用量为5 g，反应温度为60 ℃，反应时间为4 h，产品收率为90.5%，催化剂循环使用4次反应活性未见明显下降，具有较好的稳定性。

关键词：紫外线吸收剂；4-氨基苯甲酸乙酯；原甲酸三甲酯；N-甲基苯胺；合成

中图分类号：TQ246　　文献标识码：A　　文章编号：1009-9212（2022）04-0076-03

Synthesis of N-(4-Ethoxycarbonylphenyl)-N′-methyl-N′-phenyl Formamidine

LIU Liu, MENG Ji-wen (China Haohua (Dalian) Research & Design Institute of Chemical Industry Co., Ltd., Dalian 116023, China)

Abstract：N-(4-Ethoxycarbonylphenyl)-N'-methyl-N'-phenyl formamidine was synthesized through one step from ethyl 4-aminobenzoate, trimethyl orthoformate and N-methylaniline with active Al2O3 as catalyst. The effects of raw material ratio, catalyst type, temperature and time on the reaction were investigated. The optimized process conditions were as followings: n(ethyl 4-aminobenzoate)∶n(trimethyl orthoformate)∶n(N-methylaniline) was 1.00∶1.10∶1.05; the active Al2O3 dosage was 5 g; the reaction temperature was 60 ℃; the reaction time was 4 h. Under the above conditions, a yield of 90.5% was obtained. The catalyst was recycled for 4 times with good stability.

Key words：ultraviolet absorber; ethyl 4-aminobenzoate; trimethyl orthoformate; N-methylaniline; synthesis

作者简介：刘 柳（1982—），女，辽宁锦州人，工程师，硕士，研究方向：药物中间体及精细化学品（E-mail：postboymjw@163.com）。

收稿日期：2022-05-05