第 52 卷第 5 期 | ![](image2/wentou.gif) | Vol. 52 No. 5 | 2022 年 10 月 | Oct 2022 |
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所属栏目:分析与测试
β-蒿甲醚的波谱数据和结构确证 |
张秋萍1,徐作武2,田立杰1,沈莎莎1,许婷婷1,高浩凌1*
(1. 浙江医药股份有限公司 研究院,浙江 绍兴 312300;2. 浙江医药股份有限公司 新昌制药厂,浙江 绍兴 312500) |
摘 要:通过高分辨质谱、核磁共振波谱、热分析、X射线粉末衍射对β-蒿甲醚进行了结构表征,确定了样品的分子结构和晶型。综合运用多种谱学方法确证了β-蒿甲醚的结构,为其质量研究提供参考。 |
关键词:β-蒿甲醚;波谱表征;结构确证;晶型 |
中图分类号:R285 文献标识码:A 文章编号:1009-9212(2022)05-0097-04 |
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Spectral Analysis and Structural Identification of β-Artemether |
ZHANG Qiu-ping1, XU Zuo-wu2,TIAN Li-jie1, SHEN Sha-sha1, XU Ting-ting1, GAO Hao-ling1*
(1. Research & Development Center, Zhejiang Medicine Co., Ltd., Shaoxing 312300, China; 2. Xinchang Pharmaceutical Factory, Zhejiang Medicine Co., Ltd., Shaoxing 312500, China) |
Abstract:β-Artemether was the main drug for the treatment of malaria. The structure of β-Artemether was characterized by high-resolution mass spectrometry, nuclear magnetic resonance data, thermal analysis, and X-ray powder diffraction, and the molecular structure and crystal form of the sample were determined. The structure of β-Artemether was confirmed by comprehensive use of a variety of spectroscopic methods, and a reference for its quality research was provided. |
Key words:β-Artemether; spectral characterization; structure identification; crystal form |
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作者简介:张秋萍(1968—),女,浙江新昌人,工程师,研究方向:药物研发(E-mail:zhangqiuping@zmc.top)。
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联 系 人:高浩凌,工程师,研究方向:药物合成研究(E-mail:gaohaoling89@163.com)。
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收稿日期:2022-05-23
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