| 第 53 卷第 1 期 |  | Vol. 53 No. 1 | | 2023 年 2 月 | Feb 2023 |
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所属栏目：医药及中间体
吡拉西坦合成工艺的改进 |
| 庹仪敏，向莉蓉，荆一丹，肖子丹*
（长沙理工大学 化学化工学院，湖南 长沙 410000） |
| 摘 要：以α-吡咯烷酮为起始原料，经与甲醇钠反应得到吡咯烷酮钠盐（2），再与氯乙酸甲酯缩合得到吡咯烷酮乙酸甲酯（3），最后经过氨解反应得吡拉西坦（1）。该制备方法三废少、污染小、效率高、收率高，具有工业化应用前景。 |
| 关键词：吡拉西坦；乙酰胺吡咯烷酮；α-吡咯烷酮；吡咯烷酮乙酸甲酯 |
| 中图分类号：TQ460.31 文献标识码：A 文章编号：1009-9212（2023）01-0039-03 |
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| Synthesis of Piracetam |
| TUO Yi-min, XIANG Li-rong, JING Yi-dan, XIAO Zi-dan*
(School of Chemistry and Chemical Engineering, Changsha University of Science & Technology, Changsha 410000, China) |
| Abstract：Using 2-pyrrolidone as starting material, pyrrolidone sodium salt (2) was prepared by substitution reaction; methyl pyrrolidone acetate (3) was obtained by the condensation reaction of 2; finally piracetam (1) was obtained by the ammonolysis reaction of 3. This preparation method has the advantages of less waste, less pollution, high efficiency and high yield, and has the prospect of industrial application. |
| Key words：Piracetam; 2-(2-oxopyrrolidino)acetamide; 2-pyrrolidinone; methyl 2-pyrrolidone-1-acetate |
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作者简介：庹仪敏（2001—），女，湖南常德人，研究方向：有机合成。
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联 系 人：肖子丹，研究方向：精细化工中间体（E-mail：80204942@qq.com）。
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收稿日期：2022-09-08
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