第 53 卷第 2 期Vol. 53 No. 2
2023 年 4 月Apr 2023
所属栏目：功能材料

己基咔唑衍生物电化学传感器制备及Mn2+检测应用
金美玉1，吴 比1，孙艳青1，刘欣宇1，周淑晶1，2，栾 芳1，2*，冯艳茹1，2* （1. 佳木斯大学 药学院，黑龙江 佳木斯 154007；2. 佳木斯大学 黑龙江省新药开发与药理毒理评价重点实验室，黑龙江 佳木斯 154007）
摘　要：采用vilsmeier甲酰化和羟醛缩合法合成N-己基咔唑衍生物，通过红外光谱、质谱和核磁共振氢谱对化合物结构进行表征确证；采用滴涂法制备N-己基咔唑/rGO/GCE复合电极，通过循环伏安曲线测试和阻抗测试进行表征；采用循环伏安检测Mn2+。结果表明HD4/rGO/GCE对Mn2+电化学响应较好。在扫描速度50 mV/s、pH=4的优化条件下，Mn2+浓度在2~200 μmol/L线性关系良好，最低检测限为0.298 μmol/L（S/N=3）。选取最优修饰电极用于Mn2+标准品测定，加标回收率为98.0%~101.0%。结果表明HD4/rGO/GCE具有良好的稳定性、重复性和抗干扰性。
关键词：N-己基咔唑衍生物；复合电极；循环伏安；Mn2+
中图分类号：O657.1　　文献标识码：A　　文章编号：1009-9212（2023）02-0051-07
Preparation of N-hexyl Carbazole Derivative Electrochemical Sensor and Applications for Mn2+ Detection
JIN Mei-yu1, WU Bi1, SUN Yan-qing1, LIU Xin-yu1, ZHOU Shu-jing1,2, LUAN Fang1,2*, FENG Yan-ru1,2* (1. Pharmacy College, University of Jiamusi, Jiamusi 154007, China; 2. Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, University of Jiamusi, Jiamusi 154007, China)
Abstract：N-hexyl carbazole derivatives were synthesized through vilsmeier formylation and hydroxyl acetylation. The structures of the compounds were characterized by infrared spectroscopy and mass spectrometry. N-hexyl carbazole/rGO/GCE composite electrode was prepared by drip coating method and characterized by cyclic voltammetry curve and impedance test. Cyclic voltammetry was used to detect Mn2+. The results showed that HD4/rGO/GCE had the best electrochemical response to Mn2+.Under the best experimental conditions of the optimal scanning speed was 50 mV/s and the pH was 4, Mn2+ concentration showed a good linear relationship between 2~200 μmol/L and the lowest detection limit was 0.298 μmol/L (S/N=3). The optimal modified electrode was selected for the determination of Mn2+ standard, and the recoveries were 98.0%~101.0%. The results showed that HD4/rGO/GCE had good stability, repeatability and anti-interference.
Key words：N-hexyl carbazole derivate; composite electrode; cyclic voltammetry; Mn2+
基金项目：黑龙江省教育厅基础科研业务费项目（2019-KYYWF-1343），佳木斯大学博士科研启动基金项目（JMSUBZ2019-12），黑龙江省新药开发与药理毒理评价重点实验室开放项目（kfkt2022-04）。
作者简介：金美玉（1998—），女，黑龙江巴彦人，硕士，研究方向：分析化学（E-mail：2696426003@qq.com）。
联 系 人：栾 芳，副教授，研究方向：有机光电材料的制备及应用（E-mail：fangfang628628@126.com）；冯艳茹，副教授，研究方向：有机小分子设计合成及其应用（E-mail：nancy_fyr@163.com）。
收稿日期：2023-03-30