| 第 33 卷第 3 期 |  | Vol. 33 No. 3 | | 2003 年 6 月 | Jun 2003 |
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所属栏目：其它
发作性睡眠治疗药莫达非尼的合成 |
| 王巧玲; 刘智凌; 卢其慧; 廖文文; 王晓光(长沙环境保护职业技术学院; 湖南化工研究院; 深圳科达科药物科技有限公司; 410000; 410007; 518115) |
| 摘 要：以二苯甲酮为原料 ,经催化合成二苯甲醇 ,再与 2-巯基乙酸反应合成 2-二苯甲基硫代乙酸 ,再经SOCl2 氯化 ,氨水氨化和H2O2 氧化合成产品莫达非尼 ,熔点 164～165.5℃ ,含量 99% ,总收率 66.8%。 |
| 关键词：莫达非尼; 二苯甲酮; 二苯甲醇 |
| 中图分类号：TQ225.26 文献标识码：A 文章编号：1009-9212(2003)03-0026-02 |
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| Synthesis of the Modifinil |
| WANG Qiao-ling etc.（Changsha Environmental Protection College; Hunan Changsha; 410004; China） |
| Abstract：The modifinil was synthesized from benzophenone as material. As first, the benzophenone was reduced to benzhydrol, then, which reacted with 2 thioglycollic acid to produce 2 diphenyl methylthioacetic acid, which was chloriated by SOCl 2, aminated by ammonia and then exidized by H 2O 2. The melt point of the product is 164～165?℃, Content 99%, and the overall yield 66.8%. |
| Key words：modafihil; benzophenon; benzhydrol |
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收稿日期：2003-05-12
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