| 第 33 卷第 4 期 |  | Vol. 33 No. 4 | | 2003 年 8 月 | Aug 2003 |
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所属栏目：其它
苯氧菌酯的合成研究 |
| 刘卫东; 徐道庄; 杜升华; 吴光群(湖南化工研究院; 湖南长沙) |
| 摘 要：以苯酞和邻甲酚为起始原料 ,生成物经酰氯化、酰氰化、水解反应得苯基草酸甲酯衍生物 ,再与甲氧基氨盐酸反应得Z/E构型混合物。该混合物经转位反应得苯氧菌酯。反应总收率为 57.2% (以苯酞计 ) ,产品纯度为 95 %。该工艺流程简单 ,易于工业化生产 |
| 关键词：苯氧菌酯; 邻甲酚; 苯酞; 合成 |
| 中图分类号：TQ245.2+4 文献标识码：A 文章编号：1009-9212(2003)04-0010-02 |
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| The Synthesis Study on Kresoxim-methyl |
| LIU Wei dong etc.（Hunan Research Institute of Chemical Industry; Changsha; 410007; China） |
| Abstract：Kresoxim methyl was prepared by reacting the intermediate, methyl 2 (2 methylphenoxymethyl) phenylglyoxylate, with O-methylhydroxylamine hydrochloride. The resulting E/Z isomer mixture was treated with hydrochloride for substantial rearrangement of the Z to the E isomer. The intermediate was synthesized by using O cresol, phthalide, thionyl chloride, and sodium cyanide as raw materials. The total yield of the five steps reaches 57.2% (according to phthalide), and the process is convinient and suitable f... |
| Key words：Kresoxim-methyl; O cresol; phthalide; synthesis |
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收稿日期：2003-05-08
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