| 第 33 卷第 5 期 |  | Vol. 33 No. 5 | | 2003 年 10 月 | Oct 2003 |
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所属栏目：其它
抗抑郁药奈法唑酮中间体2-苯氧乙胺的合成工艺改进 |
| 章小波; 蒋永祥(浙江大学化学系; 浙江杭州) |
| 摘 要：以乙腈为原料与乙醇胺反应制得 2-甲基-2-口恶唑啉 ,再与苯酚反应 ,水解得到所需产物 2-苯氧乙胺 ,对工艺进行了改进 ,收率提高到 51.5 % ,成本低 ,有一定的工业应用前景。 |
| 关键词：2-甲基-2-口恶唑啉; N-（2-苯氧乙基）乙酰胺; 2-苯氧乙胺; 合成 |
| 中图分类号：TQ226.38 文献标识码：A 文章编号：1009-9212(2003)05-0028-02 |
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| The Improved Synthetic Technology of Antidepressant Nefazodone Intermediate-2-Phenoxyethanamine |
| ZHANG Xiao-bo; etc （Department of Chemistry; Zhejiang University; Hangzhou Zhejiang 310027; China） |
| Abstract：Some improvements were made in the synthesic process of 2-phenoxyethanamine, and the condition was more moderate, and the cost was lower. The overall yield is 51.5%, and the method is more suitable for industrial process. |
| Key words：methyl-2-oxazoline; N-（2-phenoxyethyl）acet-amide; 2-phenoxyethanamine; synthesis |
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收稿日期：2003-07-21
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