| 第 33 卷第 5 期 |  | Vol. 33 No. 5 | | 2003 年 10 月 | Oct 2003 |
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所属栏目：专论与综述
头孢中间体GCLE的研究开发进展 |
| 杨莉; 刘智凌; 徐满才(湖南师范大学化学化工学院; 湖南化工研究院; 湖南长沙) |
| 摘 要：综述了 7-苯乙酰胺-3-氯甲基头孢烷烯酸对甲氧基苄酯 (GCLE)的三种合成路线。并介绍了GLCE的用途。 |
| 关键词：GCLE; 头孢中间体; 氯化; 闭环 |
| 中图分类号：R978.1 文献标识码：A 文章编号：1009-9212(2003)05-0001-04 |
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| The Progress in the Research of GCLE as a Reactive Intermediate for Cephalosporin Antibiotics |
| YANG Li~1; LIU Zhi-ling~2; etc（1.Department of Chemical Engineering; Hunan normal university; Changsha Hunan 410081; China; 2.Hunan Research Institute of Chemical Industy; Hunan Changsha 410007; China） |
| Abstract：Three synthetic methods as well as characteristic features of 3-chloromethyl-△~3-cephem(GCLE), a new reactive intermediate for the synthesis of a wide variety of antibiotics of cephalosporin, are described.The synthetic utility of GCLE are also described. |
| Key words：GCLE; cephalosporin intermedfiate; chloridize; ring closure |
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收稿日期：2003-08-29
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