第 33 卷第 6 期 Vol. 33 No. 6 2003 年 12 月 Dec 2003

所属栏目：其它 黄连素β-环糊精包合物的制备及抑菌试验研究

李志平; 欧阳玉祝; 章爱华; 吴酝(吉首大学化学化工学院; 湖南吉首)

摘　要：用正交实验法制备了黄连素β 环糊精包合物,考察了环糊精用量、反应时间和黄连素用量等因素对包合物的影响。用紫外分光光度法测定了包合物的溶解度和包结比,并对包合物与黄连素的抑菌能力作了比较。实验结果表明:黄连素用量为0.030g,β 环糊精2.0g,包合时间90min,包合物收率可达68%以上。包合物的溶解度为4.826g/100ml水,包结比为1:2,抑菌试验表明:包合物的抑菌能力比黄连素稍有增强。

关键词：黄连素; 包合物; β-环糊精

中图分类号：R975+.3　　文献标识码：A　　文章编号：1009-9212(2003)06-0046-03

A Study on Preparation of Inclusion Complexes of Berberine with β-Cyclodextrin and Bacterium Test

LI Zhi ping; etc （College of Chemistry and Chemical engineering; Jishou University; Jishou Hunan 416000; China）

Abstract：The inclusion complexes of berberine with β Cyclodextrin were made by orthonormal test. The factors, such as the amount of β Cyclodextrin and berberine, and reacting times on inclusion reaction, were investigated. Solubility and molar ratio of β Cyclodextrin inclusion complexes was measured by U vis spectrophoto metry, and the ability of bacteriostatic was compared. The results show that when the amount of berberine and β Cyclodextrin is 0.03g and 2.0g, and the reacting time 90min, the ratio of inclus...

Key words：berberine; inclusion complexes; β-Cyclodextrin

基金项目：湖南省教育厅资助课题(01C300)

收稿日期：2003-06-30

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