第 33 卷第 6 期Vol. 33 No. 6
2003 年 12 月Dec 2003

所属栏目:其它

2-氰基-4-甲基联苯的合成研究
余红霞(武汉化工学院化工与制药学院; 湖北武汉)
摘 要:以溴化亚铜为催化剂,将邻苯甲腈与对溴甲苯偶联制备了合成沙坦类药物的关键中间体2-氰基-4'-甲基联苯,收率50%。
关键词:2-氰基-4'-甲基联苯; 合成; 溴化亚铜
中图分类号:TQ243.3  文献标识码:A  文章编号:1009-9212(2003)06-0040-01
The Synthesis of 2-Cyano-4’-Methyl Phenylbenzene
YU Hong xia.(School of Chemical Technology & Pharmaceutics; Wuhan Institute of Chemical Technology; Wuhan Hubei 430073; China)
Abstract:cyano 4' methyl phenylbenzene, a key intermediate of Sartan drug, was synthesized from 4 bromotoluene and 2 bromobenzonitrile in the present of cuprous bromide as a catalyst. The yield is 50%.
Key words:cyano-4'-methyl phenylbenzene; synthesis; cuprous bromide
收稿日期:2003-06-23
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