第 34 卷第 1 期 Vol. 34 No. 1 2004 年 2 月 Feb 2004

所属栏目：其它 5-取代-1H-1,2,4-三氮唑-3-羧酸的合成及结构表征

李德江; 孙碧海; 李斌(湖北省丹江口市郧阳师范专科学校化学系; 武汉化工学院制药工程系; 湖北丹江口市; 湖北武汉)

摘　要：以5 氯基 1H 1,2,4 三氮唑 3 羧酸乙酯为原料,经Sandmeyer反应合成了5 取代 1H 1,2,4 三氮唑 3 羧酸乙酯,其中取代基为氯、溴、碘、氰基等。并通过UV,IR,1HNMR和元素分析对所有产物的结构进行了表征。

关键词：5-氨基-1H-1; 2; 4-三氮唑-3-羧酸乙酯; Sandmeyer反应; 合成; 表征

中图分类号：TQ252.6　　文献标识码：A　　文章编号：1009-9212(2004)01-0035-03

The Synthesis of 5-Substituting group-1H-1,2,4-Triazole-3-Carboxylic Acid Ethyl Ester

LI De-jiang~1; SUN Bi-hai~2; LI Bin~2 （1.Department of Chemistry; Yunyang Teachers College; Danjiangkou 442700; China; 2.Department of Pharmaceutical Technology; Wuhan Institute of Chemical Technology; Wuhan 430073; China）

Abstract：1H-1,2,4-triazole derivatives,owing to their extensive uses in pharmaceutical synthesis,in an effort to search for more useful reaction intermediates containing 1H-1,2,4-triazole, four new 5-substituted-1H-1,2,4-triazoles were synthesized from 5-amino-1H-1,2,4-triazole-3-carboxylic acid ethyl ester by Sandmeyer reaction. Their structures were confirmed by elementl analysis, IR, UV and ~1 HNM.

Key words：5-amino-1H-1; 2; 4-triazole-3-carboxylic acid ethyl ester; Sandmeyer reactipn; synthesis; characterization

收稿日期：2003-08-22

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