第 34 卷第 2 期 Vol. 34 No. 2 2004 年 4 月 Apr 2004

所属栏目：其它 3-芳胺甲烯基-6-甲基-6-胡椒基-5,6-二氢-2H-吡喃-2,4二酮的合成及杀菌活性

邱克明; 王有名; 何可(湖南省张家界市环保局; 元素有机化学重点实验室南开大学元素有机化学研究所; 湖南张家界)

摘　要：采用乙酰乙酸乙酯的双负离子与胡椒基甲基酮反应,合成了5,6 二氢 6 甲基 6 胡椒基 2H 吡喃 2,4 二酮,然后与原甲酸三乙酯、芳胺进行缩合反应,得到了3 芳胺甲烯基 5,6 二氢 6 甲基 6 胡椒基 2H 吡喃 2,4 二酮,其结构经1HNMR和元素分析证实。生物活性初步测定表明,该类化合物具有一定的杀菌活性。

关键词：双负离子; 胡椒基甲基酮; 杀菌

中图分类号：TQ455　　文献标识码：A　　文章编号：1009-9212(2004)02-0011-03

Synthesis and Fungicidal Activity of 3-Anilinomethylene-5,6-dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-diones

QIU Ke-ming~1; WANG You-ming~2; HE Ke~2 （1; Bureau of Enviroment Protection; Zhangjiajie 427000 china; 2; State Key Laboratory of Elemental-Organic Chemistry; Institute of Elemental-Organic Chemistry; Nankai University; Tianjin; 300071; China）

Abstract：5, 6-Dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-dione, which was obtained by reacting dianion of acetoacetate with piperonyl methyl acetone, reacted with substituted anilines in the presence of ethyl orthoformate and 3-anilinomethylene-5, 6-dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-diones (2) were obtained.The Structures of compounds 2 were confirmed by 1~H NMR spectra and elemental analyses. Compound 2 was tested in vitro against many fungi such as P. Zeae, A. Solani, R. Solani, P. Piricola, C. Arachidica...

Key words：Dianion; Piperonyl methyl acetone; Fungicidal activity

基金项目：国家自然科学基金青年基金资助(20302003)。

收稿日期：2004-02-17

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