| 第 34 卷第 3 期 |  | Vol. 34 No. 3 | | 2004 年 6 月 | Jun 2004 |
|
所属栏目：其它
液相催化加氢制备普鲁卡因 |
| 贾志刚; 祝清兰; 李方实(南京工业大学理学院) |
| 摘 要：采用Raney镍催化剂,在二甲苯溶剂中,温度130℃,氢压3MPa,硝基卡因催化加氢制备普鲁卡因。反应时间7h。加氢转化率达95%以上。普鲁卡因收率83.5%。纯度达98%。用红外、重氮化滴定等对产物进行定性、定量分析。 |
| 关键词：催化加氢; 硝基卡因; 普鲁卡因; Raney镍 |
| 中图分类号：TQ245.2+4 文献标识码：A 文章编号：1009-9212(2004)03-0032-03 |
|
| Preparation of Procaine by Catalytic Hydrogenation |
| JIA Zhi-gang; ZHU Qing-lan; LI Fang-shi（Nanjing University of Technology; Nanjing 210009; China） |
| Abstract：A new method was developed for the preparation of procaine by catalytic hydrogenation in the presence of Raney-Ni. The optical condition was temperature 130 ℃, hydrogen pressure 3.0 MPa, reaction time 7 h. The conversion rate is 95%. The yield of procaine is 83.5%. The purity is up to 98%. The product was determined by UV, IR, and diazotization titration for qualitative and quantitative analysis respectively. |
| Key words：catalytic hydrogenation; p-nitrobenzoic acid-2-（diethylamino）ethyl ester; procaine; Raney-Ni |
|
收稿日期：2003-12-18
|
| 阅读全文 |
|