第 34 卷第 3 期 Vol. 34 No. 3 2004 年 6 月 Jun 2004

所属栏目：其它 强酸性离子交换膜催化合成5-乙氧羰基-4-(4-甲氧苯基)-6-甲基-3,4-二氢嘧啶-2(1H)-酮

李治; 施婷婷; 倪淑晶(华东理工大学化学与制药学院)

摘　要：在HF-101强酸性离子交换膜的存在下,由茴香醛、乙酰乙酸乙酯与脲一步合成了5 乙氧羰基 4 (4 甲氧苯基) 6 甲基 3,4 二氢嘧啶 2(1H) 酮。当茴香醛、乙酰乙酸乙酯与脲的摩尔比为1:2:5,乙醇作溶剂,4g离子交换膜,回流2h,产物收率达95 2%。同时研究了离子交换膜作为催化剂的重复使用情况。

关键词：强酸型离子交换膜; 催化; 药物中间体; 5-乙氧羰基-4-（4-甲氧苯基）-6-甲基3; 4-二氢嘧啶-2-（1H）-酮

中图分类号：TQ254.1　　文献标识码：A　　文章编号：1009-9212(2004)03-0020-02

Synthesis of 5-ethoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one by Catalysis of Strong Acidic Ion-exchange Membrane

LI Zhi; SHI Ting-ting; NI Shu-jing （East China University of Science and TEchnology; Shanghai 200237; China）

Abstract：5-ethoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one was synthesized from anisaldehyde, ethyl acetoactate, and urea in presence of HF-101 strong acidic ion-exchange membrane. The yield of the 3,4-dihydropyrimidin-2(1H)-one was up to 95.2% under the optimum cordition: moler ratio of anisaldehyde, ethyl acetoactate and urea 1:2:5, ion-exchange membrane 4 g, ethyl alcohol as solvent and refluxing for 2 h. The reusability of the catalyst was studied.

Key words：HF-101 strong acidic ion-exchang membrane; catalysis; pharmaceutical intermediate; synthesis; 5-ethoxycarbonyl-4-（4-methoxyphenyl）-6-methyl-3; 4-dihydropyrimidin-2（1H）-one

收稿日期：2004-03-11

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