| 第 34 卷第 4 期 |  | Vol. 34 No. 4 | | 2004 年 8 月 | Aug 2004 |
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所属栏目：其它
法昔洛韦原料的合成工艺研究 |
| 金义翠(南京工业大学制药与生命科学学院; 江苏南京) |
| 摘 要：对法昔洛韦的生产工艺中的反应时间、温度、试剂的选择等进行探索、改进,使总收率从21%提高到30%,纯度达到99%以上,该工艺降低了生产成本,更适合工业化生产。 |
| 关键词：法昔洛韦; 药物; 工艺改进 |
| 中图分类号：TQ0626.32 文献标识码：A 文章编号：1009-9212(2004)04-0039-03 |
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| A Novel Synthesis Technology of Famciclovir |
| JIN Yi-cui （Nanjing University of Technology; Nanjing 210019; China） |
| Abstract：Famciclovir is a kind of new antiviral drug, which has a wide market prospect. In view of the present problems in the synthesis of Famciclovir and a large amount of literature, the optimum technology including reaction time, temperature , reagent, etc was studied. The overall yield was raised from less than 21% to about 30%, and the purity reaches above 99% in improved method. The process has the advantage of lower cost, so it can meet the requirements of industrial production. |
| Key words：amciclovir; drug; improved synthesis |
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收稿日期：2004-05-20
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