| 第 34 卷第 4 期 |  | Vol. 34 No. 4 | | 2004 年 8 月 | Aug 2004 |
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所属栏目：其它
抗肿瘤药氟达拉滨的合成 |
| 张奎; 许燕红(杭州电化集团研发中心; 杭州达康化工有限公司) |
| 摘 要：以鸟苷为起始原料,将其6位的酮基和2位的氨基分别转换成氨基和氟,并将原来的呋喃糖部分转换成阿拉伯糖构型,成功地制备了氟达拉滨以及磷酸氟达拉滨。合成反应总收率为15.2%。 |
| 关键词：氟达拉滨; 磷酸氟达拉滨; 鸟苷; 合成 |
| 中图分类号：TQ463+5 文献标识码：A 文章编号：1009-9212(2004)04-0033-03 |
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| Synthesis of Fludarabine |
| ZHANG Kui~1; XU Yan-hong~2 （1.R&D Center; Hangzhou Electrochemical Group Co. Ltd.; Hangzhou 310053; China; 2. Hangzhou Dakang Chemicals Co. Ltd.; Hangzhou 310018; China） |
| Abstract：A process for the production of fludarabine and fludarabine phosphate was provided, wherein the guanosine was employed as the starting material,which is subjected to conversion of the 6-keto and 2-amino group to 6-amino and 2-fluoro group respectively, and conversion of ribofuranosyl moiety to arabinofuranosyl moiety .The overall yield of the process is 15.2%. |
| Key words：fludarabine; fludarabine phosphate; guanosine; synthesis |
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收稿日期：2004-03-01
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