第 31 卷第 2 期 Vol. 31 No. 2 2001 年 4 月 Apr 2001

所属栏目：其它 异丁腈合成2-异丙基-4-甲基-6-羟基嘧啶的研究

郑志明;(浙江永农化工研究所;)

摘　要：介绍了以异丁腈为原料 ,与氯化氢、氨气反应合成异丁脒盐酸盐 ,在水溶液中同乙酰乙酸甲酯反应合成 2 异丙基 4 甲基 6 羟基嘧啶的工艺路线 ,总收率达到 83% ,含量达到 98%以上。

关键词：异丁腈; 乙酰乙酸甲酯; 2-异丙基-4-甲基-6-羟基嘧啶;

中图分类号：TQ254.1　　文献标识码：A　　文章编号：1009-9212(2001)02-0021-02

Study on the Process of Isobutyronitrile to 2-isopropyl-4-methyl-6-hydroxypyridine

ZHENG Zhi ming （Zhejiang Yongnong Chemical Industry Institute; Wenzhou 325024; China）;

Abstract：A synthetic route for preparation of 2 isopropyl 4 methyl 6 hydroxypyridine is introduced in this article, which is started with Isobytyronitrile, reacting with Hydrogen Chloride and free ammonia to make Isobutyl amidine hydrochioride, then the said product is synthesed byreaction with Methyl Acetoacetate in water solution. The total yield is 83%, and purity is up to 98% min.

Key words：isobytyronitrile; methyl acetoacetate; 2 isopropyl 4 methyl 6 hydroxypyridine;

收稿日期：2001-02-06

阅读全文