第 35 卷第 1 期 Vol. 35 No. 1 2005 年 2 月 Feb 2005

所属栏目：其它 6-羟基-2-乙酰萘的制备

张广; 李加荣; 李文婷(北京理工大学化工与环境学院新医药研发中心)

摘　要：采用6 甲氧基 2 乙酰萘与浓盐酸在缚酸剂三乙胺存在的条件下进行水解反应制得6 羟基 2 乙酰萘。同时通过正交设计研究了反应的优化条件,即 6 甲氧基 2 乙酰萘、浓盐酸、三乙胺与二氯甲烷的比例为:1 g∶90 ml∶0.75 ml∶2.5 ml,反应收率为 79%。反应监控为TLC(展开剂为:正庚烷、二氯甲烷和丙酮=3∶6∶2.5,v/v)。盐酸的用量大幅度降低,产品成本降低36%。

关键词：老年痴呆; 探针技术; 6-羟基-2-乙酰萘; 水解

中图分类号：TQ241.5　　文献标识码：A　　文章编号：1009-9212(2005)01-0055-03

The preparation of 6-hydroxy-2-acetonaphthene

ZHANG Guang; LI Jia-rong; LI Wen-ting（Beijing Institute of Technology; College of Chemical Engineering & Environment; Center of New Drugs Discovery; Beijing 100081; China）

Abstract：hydroxy-2-acetonaphthene was obtained by the hydrolysis of 6-methoxy- 2-acetonaphthene in the presence of HCl (36%) and triethylamine as a catalyst. The optimum conditions were studied by orthogonal design. The ratio of 6-methoxy-2-acetonaphthene/ conc.HCl/Et_(3)N/CH_(2)Cl_(2) was 1∶90∶0.75∶2.5(g∶v∶v∶v), and the yield was 79%. The reaction was monitored by TLC, and the developed solution.was n-heptane:CH_(2)Cl_(2):acetone (3∶6∶2.5, v/v). The consumption of HCl was reduced greatly and the cost was dropped by...

Key words：Alzheimer’s disease; probe technique; 6-hydroxy-2-acetonaphthene; hydrolysis

基金项目：北京理工大学基础资金资助(No 000Y05)。

收稿日期：2004-05-28

阅读全文