| 第 35 卷第 2 期 |  | Vol. 35 No. 2 | | 2005 年 4 月 | Apr 2005 |
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所属栏目：其它
N,N-二乙基-3,7-二甲基(E)-2,6-辛二烯-1-胺的合成研究 |
| 王志军; 臧健; 吴怡祖(南京工业大学化学与化工学院; 江苏南京) |
| 摘 要：以二乙胺(DEA)和月桂烯(MYE)为原料,在有机锂的催化下合成了重要的有机中间体N,N二乙基牛儿胺(GDEA)。对反应机理进行了简述,建立了GDEA的气谱分析条件,考察了不同因素对反应的影响,确定了优惠反应条件:以环己烷为溶剂,原料配比n(DEA):n(MYE)=2.5∶1,催化剂用量与月桂烯的摩尔比为15%,反应温度为DEA的回流温度,反应时间为12h。产品摩尔收率>85%,产品经减压分馏后纯度>95%。 |
| 关键词：手性药物前体; N; N-二乙基■牛儿胺; 月桂烯; 气相色谱分析 |
| 中图分类号：TQ226.32 文献标识码：A 文章编号：1009-9212(2005)02-0042-03 |
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| A Study on synthesis of N, N-Diethyl-3,7-dimethyl-(E)-2,6-octadien-1-amine |
| WANG Zhi-jun; ZANG Jian; ~（ ）WU Yi-zu（College of chemistry and chemical engineering; Nanjing University of technology; Nanjing 210009; China） |
| Abstract：A key organic intermediate N, N-diethylgeranylamine(GDEA) was prepared from diethylamine (DEA) and myrcene (MYE), when organic lithium as the catalyst. The mechanism of reaction was discussed, the optimized GC analysis was established, the influence of the reaction was studied, and the optimum conditions of the reaction were as follow: the cyclohexane as solvent, the mole ratio n (DEA): n (MYE) =2.5:1, the catalyst mole ratio to MYE is 15%, reaction temperature is the refluxed temperature of DEA, reaction t... |
| Key words：Prochiral pharmaceutical intermediate; N; N-diethylgeranylamine; myrcene; GC |
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收稿日期：2004-12-11
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