第 35 卷第 2 期 Vol. 35 No. 2 2005 年 4 月 Apr 2005

所属栏目：其它 除草剂炔草酯的合成研究

陈强; 廖文文; 刘智凌(江苏宝灵化工股份有限公司; 湖南师范大学化学化工学院; 湖南化工研究院; 江苏南通; 湖南长沙)

摘　要：以5氯2,3二氟吡啶与(R)2(对羟基苯氧基)丙酸为原料,以二甲基甲酰胺(DMF)为溶剂,K2CO3为缚酸剂,在70℃下醚化反应4h,然后再加入氯丙炔,以甲苯为溶剂,反应温度70～75℃,降温后过滤除盐,DMF洗涤,脱溶,再用乙醇/水结晶,干燥得产品,含量98%,以(R)2(对羟基苯氧基)丙酸计总收率86%。

关键词：炔草酯; 顶尖; 除草剂; 5-氯-2; 3-二氟吡啶; R-2-（对羟基苯氧基）丙酸

中图分类号：TQ457.2　　文献标识码：A　　文章编号：1009-9212(2005)02-0035-02

Synthesis of the herbcidal chodinafop-propargyl

CHEN Jing~（1）; LIAO Wen-wen~（2）（1.Jiangsu Baoling Chemical Co Ltd; Nantong 226006; China; 2.Hunan Normal University; Changsha 410082; 3.Hunan Research Institute of Chemical Industry; Changsha 410007; China）

Abstract：Chodinafop-propargyl was synthesized from R-2-(p-hydroxyphenoxy)-propionic acid and 5-chloro 2,3-difluoropyridine and propargyl chloride. At first R-2-(p-hydroxyphenoxy)-propionic acid was converted into the corresonding potassium with potassium carbonate powder and tetrabutyl ammonium bromide in DMF at 70℃,then 5-chloro–2,3-difluoropyridine was added over course of 30 min ,after 4 hours, propargyl chloride was added over 2 hours to form the (R)(+)-2-[4-(5-chloro-3-fluoropyridin-2-yloxy)-phenoxy]-propionic ...

Key words：chodinafop-propargyl; Topic; herbcidal; l; 5-chloro–2; 3-difluoropyridine; R-2-（p-hydroxyphenoxy）-propionic acid

收稿日期：2004-02-26

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