第 35 卷第 2 期 Vol. 35 No. 2 2005 年 4 月 Apr 2005

所属栏目：其它 1-乙酰氨基-3,5-二甲基金刚烷的水解反应研究

任会学; 林吉茂; 薛云; 李红梅; 冯永斌(山东大学化学与化工学院; 山东济南)

摘　要：通过对酰胺水解反应的机理的分析,针对1乙酰氨基3,5二甲基金刚烷空间位阻大、取代基为推电子基团的特点,对其水解反应对收率的影响进行了研究。结果表明:此化合物的水解适宜在碱性条件下进行,且在n(反应物)∶n(苛性钠)=1∶5,溶剂为水:乙二醇=1∶10,150℃下反应12h,得到最终产品盐酸美金刚的收率为92.5%,纯度为99.5%

关键词：1-乙酰氨基-3; 5-二甲基金刚烷; 水解反应; 盐酸美金刚

中图分类号：O624.1　　文献标识码：A　　文章编号：1009-9212(2005)02-0029-03

Study on the Hydrolytic Reaction of the 1-Acetamido-3,5-Dimethyladamantane

REN Hui-xue; LIN Ji-mao; XUE Yun; LI Hong-mei; FENG Yong-bin（School of Chemical and Engineering of Shandong University; Jinan 250100; China）

Abstract：Through analyzing the mechanism of the hydrolysis of amides,the effects of the hydrolysis on yields of the product were studied.According to the special character of 1-acetamido-3,5-dimethyladamantane,which has big special resistance and substituents pushing electron group.The optimum condition is as follows:hydrolized in alkaline condition,n(reactant)∶n(alkali)=1∶5,the solvent is the mixture of water and ethylene glycol 1∶10(v/v),and the reaction is kept at 150 ℃ for 12 h.The yield of product is 92.5%,the ...

Key words：1-acetamido-3; 5-dimethyladamantane; hydrolysis; memantine hydrochloride

收稿日期：2004-12-15

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